Just a thought
I've been watching Prison Break lately - and really enjoying it by the by. And Robin Tunney's presence - with hair - has made me realize how much she looks like Alexis Bledel.
They should definitely play sisters in something. And either their older sister or freakishly young mother should be played by another teen tv star, Moira Kelly (of One Tree Hill).
While we're on the topic of people looking like things, here are a few more anime candidates: